The Tryptophan Load Test in Gluten Sensitive Steatorrhoea

A Screening Test for Steatorrhoea

During recent years there has been increasing interest in the study of fat absorption, particularly in the investigation of conditions associated with steatorrhoea. The need for a single diagnostic test for steatorrhoea, suitable for use with both outpatients and in-patients, has become apparent. Ideally, such a test should be easy to carry out for the patient and nursing staff as well as for t...

Transglutaminases in Gluten Sensitive Diseases

The Nile blue test in the detection of steatorrhoea.

The Nile blue test for the detection of steatorrhoea has been compared with the estimation of 24-hour faecal excretion by the method of Weijers and Van der Kamer modified by Anderson, Frazer, French, Gerrard, Simmons, and Smellie (1952). The Nile blue test is easily and quickly carried out. A positive result was only found in cases showing a considerable degree of steatorrhoea but it was often ...

Gluten-sensitive enteropathy: Synthesis

The intestinal mucosa of patients with gluten-sensitive enteropathy responds to gluten challenge in vivo with a striking increase in IgA and IgM synthesis. Whether this increase in immunoglobulin synthesis is due in some part to the production of antigliadin antibodies is examined. Using an affinity chromatography technique it has been demonstrated that in six of seven patients with gluten-sens...

The effect on jejunal mucosa of withdrawing and adding dietary gluten in cases of idiopathic steatorrhoea.

Biopsy studies of the jejunal mucosa in patients with idiopathic steatorrhoea after periods on a gluten-free diet showed that the epithelium improved quickly in respect of surface cell height, mucosal thickness, and mitosis count, and more slowly in respect of villous height and width. In no case was recovery complete in every particular. Appearances seen through the dissecting microscope impro...